Prostate | Mind-Body-Spirit for Health

Managing hot flushes in men after prostate cancer-A systematic review.

December 8, 2009

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Managing hot flushes in men after prostate cancer-A systematic review.

Maturitas. 2009 Dec 3;

Authors: Frisk J

CONTEXT AND OBJECTIVE: The aim of this study was to describe hot flushes in men with prostate cancer, and their treatment methods. METHOD: A systematic review was conducted of the literature indexed between 1966 and 2009 on the MEDLINE, the ISI Web of Knowledge, Cinahl and PsycINFO. Of 252 articles identified, 32 were selected for consideration of their complete texts, of which five were subject to detailed analysis. RESULTS: Diethylstilbestrol, megestrol acetate and cyproterone acetate have the strongest effect, giving a 75% or larger decrease of the number of hot flushes, but they may have severe or bothersome side-effects. Gabapentin has an uncertain effect. Clonidine is not proven effective for hot flushes. Long-term effects were not evaluated in any of the studies. SSRI/SNRI and acupuncture may have a moderate effect on hot flushes but are not proven in any RCTs. CONCLUSION: Hot flushes are common and bothersome symptoms in men with prostate cancer and those taking anti-androgen treatment, and reduce quality of life. Few treatments are available and some are avoided for these patients. Additional prospective treatment studies are needed, with long-term follow-up, in order to evaluate the effects and risks of treatments. Treatments with few or no severe side-effects should be prioritised in future investigations. Experimental studies are also needed to elucidate the mechanism behind hot flushes in men and to suggest routes for the development of new treatments.

PMID: 19962840 [PubMed - as supplied by publisher]

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Acupuncture may help improve enlarged prostate

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TAIPEI, Taiwan — Acupuncture may help improve conditions for those with benign prostatic hyperplasia (BPH), or enlarged prostate glands, and could stand in …

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Among Men Living With Early, Untreated Prostate Cancer, Study Finds Acceptable Levels Of Anxiety

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Men with early stages of prostate cancer who delay radical treatment in favor of an approach of “expectant management” do not have high levels of anxiety and distress. That is the conclusion of a new study published in the September 1, 2009 issue of Cancer, a peer-reviewed journal of the American Cancer Society. The study’s results suggest that living with untreated cancer is not upsetting for many patients with early prostate cancer.

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A Novel Communication Role For CYP17A1 In The Progression Of Castration-Resistant Prostate Cancer

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UroToday.com – This publication describes our unique finding that the steroidogenic enzyme CYP17A1 is present in prostate derived exosomes, isolated from human serum.